An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia.
Authors
Yudhaputri, Frilasita A
Powers, Ann M
Publication Date
2020-12-21Journal Title
PLoS neglected tropical diseases
ISSN
1935-2727
Volume
14
Issue
12
Pages
e0008934
Language
eng
Type
Article
This Version
AM
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Stubbs, S. C., Johar, E., Yudhaputri, F. A., Yohan, B., Santoso, M. S., Hayati, R. F., Denis, D., et al. (2020). An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia.. PLoS neglected tropical diseases, 14 (12), e0008934. https://doi.org/10.1371/journal.pntd.0008934
Abstract
Background
Chikungunya virus (CHIKV) is an important emerging and re-emerging public health problem worldwide. In Indonesia, where the virus is endemic, epidemiological information from outside of the main islands of Java and Bali is limited.
Methodology/Principal Findings
Four hundred and seventy nine acutely febrile patients presenting between September 2017 – 2019 were recruited from three city hospitals situated in Ambon, Maluku; Banjarmasin, Kalimantan; and Batam, Batam Island as part of a multi-site observational study. CHIKV RNA was detected in a single serum sample while a separate sample was IgM positive. IgG seroprevalence was also low across all three sites, ranging from 1.4 – 3.2%. The single RT-PCR positive sample from this study and 24 archived samples collected during other recent outbreaks throughout Indonesia were subjected to complete coding region sequencing to assess the genetic diversity of Indonesian strains. Phylogenetic analysis revealed all to be of a single clade, which was distinct from CHIKV strains recently reported from neighbouring regions including the Philippines and the Pacific Islands.
Conclusions/Significance
Chikungunya virus strains from recent outbreaks across Indonesia all belong to a single clade. However, low-level seroprevalence and molecular detection of CHIKV across the three study sites appears to contrast with the generally high seroprevalences that have been reported for non-outbreak settings in Java and Bali, and may account for the relative lack of CHIKV epidemiological data from other regions of Indonesia.
Sponsorship
UK Medical Research Council (MR/P017541/1) held by SDWF and the Indonesian Science Fund (DIPI) and Indonesia Endowment Fund for Education (LPDP) held by RTS (MRCUK6) as part of the UK-Indonesia Joint Health Research Call on Infectious Diseases (2016). SDWF was supported in part by The Alan Turing Institute via an Engineering and Physical Sciences Research Council grant (EP/510129/1)
Funder references
MRC (MR/P017541/1)
Embargo Lift Date
2023-11-02
Identifiers
External DOI: https://doi.org/10.1371/journal.pntd.0008934
This record's URL: https://www.repository.cam.ac.uk/handle/1810/312349
Rights
All rights reserved