A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow.
Accepted version
Peer-reviewed
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Repository DOI
Change log
Authors
May, Oliver
Blakemore, David C
Abstract
Mild cross-coupling reaction between benzylboronic esters with carbonyl compounds and some imines was achieved under visible-light-induced iridium-catalyzed photoredox conditions. Functional group tolerance was demonstrated by 51 examples, including 13 heterocyclic compounds. Gram-scale reaction was realized through the use of computer-controlled continuous flow photoreactors.
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Keywords
0305 Organic Chemistry
Journal Title
Org Lett
Conference Name
Journal ISSN
1523-7060
1523-7052
1523-7052
Volume Title
21
Publisher
American Chemical Society (ACS)
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All rights reserved
Sponsorship
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
Uniqsis Ltd and Mark Ladlow for the generous loan 236
of a Photosyn reactor. Y.C. thanks Pfizer for funding the 237
postdoctoral fellowship. The authors also gratefully acknowl- 238
edge financial support from H2020-FETOPEN-2016-2017 239
program of European commission (S.V.L.; grant agreement 240
no.: 737266-ONE FLOW).