Environment-dependent behavioral traits and experiential factors shape addiction vulnerability.
The European journal of neuroscience
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Fouyssac, M., Puaud, M., Ducret, E., Marti-Prats, L., Vanhille, N., Ansquer, S., Zhang, X., et al. (2021). Environment-dependent behavioral traits and experiential factors shape addiction vulnerability.. The European journal of neuroscience, 53 (6), 1794-1808. https://doi.org/10.1111/ejn.15087
The transition from controlled drug use to drug addiction depends on an interaction between a vulnerable individual, their environment and a drug. Here we tested the hypothesis that conditions under which individuals live influence behavioral vulnerability traits and experiential factors operating in the drug taking environment to determine the vulnerability to addiction. The role of behavioral vulnerability traits in mediating the influence of housing conditions on the tendency to acquire cocaine self-administration was characterized in 48 rats housed in either an enriched (EE) or a standard (SE) environment. Then, the influence of these housing conditions on the individual vulnerability to develop addiction-like behavior for cocaine or alcohol was measured in 72 EE or SE rats after several months of cocaine self-administration or intermittent alcohol drinking, respectively. The determining role of negative experiential factors in the drug taking context was further investigated in 48 SE rats that acquired alcohol drinking to self-medicate distress in a schedule-induced polydipsia procedure. The environment influenced the acquisition of drug intake through its effect on behavioral markers of resilience to addiction. In contrast, the initiation of drug taking as a coping strategy or in a negative state occasioned by the contrast between enriched housing conditions and a relatively impoverished drug taking setting, facilitated the development of compulsive cocaine and alcohol intake. These data indicate that addiction vulnerability depends on environmentally determined experiential factors, and suggest that initiating drug use through negative reinforcement-based self-medication facilitates the development of addiction in vulnerable individuals.
Animals, Rats, Cocaine-Related Disorders, Cocaine, Self Administration, Behavior, Addictive, Reinforcement, Psychology
Leverhulme Trust Early Career Fellowship (ECF-2018-713) Leverhulme Trust (RPG‐2016‐117) INSERM AVENIR
Leverhulme Trust (RPG-2016-117)
Leverhulme Trust (ECF-2018-713)
Embargo Lift Date
External DOI: https://doi.org/10.1111/ejn.15087
This record's URL: https://www.repository.cam.ac.uk/handle/1810/315180
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