Show simple item record

dc.contributor.authorYordanova, Ivet A.
dc.contributor.authorCortés, Alba
dc.contributor.authorKlotz, Christian
dc.contributor.authorKühl, Anja A.
dc.contributor.authorHeimesaat, Markus M.
dc.contributor.authorCantacessi, Cinzia
dc.contributor.authorHartmann, Susanne
dc.contributor.authorRausch, Sebastian
dc.date.accessioned2020-12-29T16:17:52Z
dc.date.available2020-12-29T16:17:52Z
dc.date.issued2019-12-30
dc.date.submitted2019-07-16
dc.identifier.others41598-019-56416-9
dc.identifier.other56416
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315637
dc.descriptionFunder: Fundacion Alfonso Martin Escudero
dc.descriptionFunder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.13039/501100000268
dc.descriptionFunder: Isaac Newton Trust; doi: https://doi.org/10.13039/501100004815
dc.description.abstractAbstract: Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with varying susceptibility to Giardia muris infection. Infected BALB/c mice shed significantly more cysts compared with C57BL/6 mice. Impaired control of infection in BALB/c mice was associated with lower Th17 activity and lower IgA levels compared with C57BL/6 mice. The limited metabolic activity, proliferation and cytokine production of Th17 cells in BALB/c mice was associated with higher proportions of intestinal Foxp3+RORγt+ regulatory T cells and BALB/c mice developed increased RORγt+ Treg:Th17 ratios in response to G. muris infection. Furthermore, G. muris colonization led to a significantly reduced evenness in the gut microbial communities of BALB/c mice. Our data indicate that differential susceptibility to Giardia infections may be related to RORγt+ Treg controlling Th17 activity and that changes in the microbiota composition upon Giardia infection partially depend on the host background.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/250/2152/1566
dc.subject/631/250/347
dc.subject/631/326/417/2546
dc.subject/9
dc.subject/13
dc.subject/13/1
dc.subject/13/21
dc.subject/13/31
dc.subject/14/34
dc.subject/14/63
dc.subject/38/77
dc.subject/38/90
dc.subject/38/91
dc.subject/64/60
dc.subjectarticle
dc.titleRORγt + Treg to Th17 ratios correlate with susceptibility to Giardia infection
dc.typeArticle
dc.date.updated2020-12-29T16:17:51Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume9
dc.identifier.doi10.17863/CAM.62744
dcterms.dateAccepted2019-11-15
rioxxterms.versionofrecord10.1038/s41598-019-56416-9
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidYordanova, Ivet A. [0000-0003-4119-7308]
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn2045-2322
pubs.funder-project-idDeutsche Forschungsgemeinschaft (German Research Foundation) (GRK2046, GRK2046, GRK2046)
pubs.funder-project-idBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) (IP7/01KI1725D)


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)