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Trial of Dexamethasone for Chronic Subdural Hematoma

Published version
Peer-reviewed

Type

Article

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Authors

Hutchinson, PETER 
Turner, C 
Bond, SIMON 

Abstract

Chronic subdural hematoma is a common neurological disorder mainly affecting older people.1 It consists of a collection of blood and blood breakdown products in the intracranial subdural space that liquefies over time; the inciting event often is minor head trauma; subsequent inflammation may play a role in the pathogenesis.2 The time of onset of chronic subdural hematoma is often not known but in some instances can be presumptively dated to a head injury. The incidence of chronic subdural hematoma is increasing due to an ageing population and use of anticoagulant and antiplatelet medications.3 Chronic subdural hematoma evacuation has been projected to become the most common cranial neurosurgical operation among adults by the year 2030 in the U.S

Description

Keywords

Administration, Oral, Aged, Combined Modality Therapy, Dexamethasone, Disabled Persons, Female, Glucocorticoids, Hematoma, Subdural, Chronic, Humans, Intention to Treat Analysis, Male, Middle Aged, Reoperation, Severity of Illness Index, Treatment Outcome

Journal Title

New England Journal of Medicine

Conference Name

Journal ISSN

0028-4793
1533-4406

Volume Title

Publisher

Massachusetts Medical Society

Rights

All rights reserved
Sponsorship
NETSCC (None)
Department of Health (via National Institute for Health Research (NIHR)) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Medical Research Council (G0601022)
Medical Research Council (G0601022/1)
NIHR HTA