Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders.
Nord, Camilla L
Lawson, Rebecca P
Am J Psychiatry
American Psychiatric Association Publishing
MetadataShow full item record
Nord, C. L., Lawson, R. P., & Dalgleish, T. (2021). Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders.. Am J Psychiatry, 178 (8), 761-770. https://doi.org/10.1176/appi.ajp.2020.20091340
OBJECTIVE: Maintenance of bodily homeostasis relies on interoceptive mechanisms in the brain to predict and regulate bodily state. While altered neural activation during interoception in specific psychiatric disorders has been reported in many studies, it is unclear whether a common neural locus underpins transdiagnostic interoceptive differences. METHODS: The authors conducted a meta-analysis of neuroimaging studies comparing patients with psychiatric disorders with healthy control subjects to identify brain regions exhibiting convergent disrupted activation during interoception. Bibliographic, neuroimaging, and preprint databases through May 2020 were searched. A total of 306 foci from 33 studies were extracted, which included 610 control subjects and 626 patients with schizophrenia, bipolar or unipolar depression, posttraumatic stress disorder, anxiety, eating disorders, or substance use disorders. Data were pooled using a random-effects model implemented by the activation likelihood estimation algorithm. The preregistered primary outcome was the neuroanatomical location of the convergence of peak voxel coordinates. RESULTS: Convergent disrupted activation specific to the left dorsal mid-insula was found (Z=4.47, peak coordinates: -36, -2, 14; volume: 928 mm3). Studies directly contributing to the cluster included patients with bipolar disorder, anxiety, major depression, anorexia, and schizophrenia, assessed with task probes including pain, hunger, and interoceptive attention. A series of conjunction analyses against extant meta-analytic data sets revealed that this mid-insula cluster was anatomically distinct from brain regions involved in affective processing and from regions altered by psychological or pharmacological interventions for affective disorders. CONCLUSIONS: These results reveal transdiagnostic, domain-general differences in interoceptive processing in the left dorsal mid-insula. Disrupted mid-insular activation may represent a neural marker of psychopathology and a putative target for novel interventions.
Affect, Cognitive Neuroscience, Emotion, Homeostasis, Insula, Interoception, Neuroimaging, Transdiagnostic, Adolescent, Adult, Biomarkers, Cerebral Cortex, Humans, Interoception, Magnetic Resonance Imaging, Mental Disorders, Neuroimmunomodulation, Young Adult
Wellcome Trust (206691/Z/17/Z)
Medical Research Council (MC_UU_00005/4)
External DOI: https://doi.org/10.1176/appi.ajp.2020.20091340
This record's URL: https://www.repository.cam.ac.uk/handle/1810/317191
All rights reserved
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: email@example.com