The role of noradrenaline in cognition and cognitive disorders.
Accepted version
Peer-reviewed
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Abstract
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in neurodegenerative diseases and contributes to their cognitive and behavioural deficits. We review the evidence for a noradrenergic modulation of cognition in its contribution to Alzheimer's disease, Parkinson's disease and other cognitive disorders. We discuss the advances in human imaging and computational methods that quantify the locus coeruleus and its function in humans, and highlight the potential for new noradrenergic treatment strategies.
Description
Keywords
cognition, dementia, locus coeruleus, neurodegeneration, noradrenaline, Cognition, Cognition Disorders, Humans, Locus Coeruleus, Norepinephrine
Journal Title
Brain
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Journal ISSN
0006-8950
1460-2156
1460-2156
Volume Title
144
Publisher
Oxford University Press (OUP)
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All rights reserved
Sponsorship
Wellcome Trust (103838/Z/14/Z)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Patrick Berthoud Charitable Trust (via Charities Aid Foundation) (Unknown)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Medical Research Council (MR/M009041/1)
Wellcome Trust (220258/Z/20/Z)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Patrick Berthoud Charitable Trust (via Charities Aid Foundation) (Unknown)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Medical Research Council (MR/M009041/1)
Wellcome Trust (220258/Z/20/Z)