Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor.
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Peer-reviewed
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Authors
Tseretopoulou, Xanthippi
Murray, Matthew J
Buck, Jackie
Hook, C Elizabeth
Jackson, Claire
Abstract
BACKGROUND: Adrenal masses are rare in children and most commonly present with clinical features of virilization in the absence of activation of the pituitary axis-gonadotrophin-independent precocious puberty. OBSERVATIONS: We report an unusual case of a 7-year-old girl who presented with clinical signs suggestive of exposure to both androgens and estrogens. Imaging revealed a left-sided adrenal mass with no evidence of metastasis. She underwent successful laparoscopic unilateral adrenalectomy. Histology confirmed an adrenal adenoma. CONCLUSION: We conclude that adrenocortical tumors should be considered in children presenting with gonadotrophin-independent precocious puberty and raised estrogens.
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Keywords
Adrenal Gland Neoplasms, Adrenocortical Adenoma, Child, Estrogens, Female, Humans, Puberty, Precocious
Journal Title
J Pediatr Hematol Oncol
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Journal ISSN
1077-4114
1536-3678
1536-3678
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Publisher
Ovid Technologies (Wolters Kluwer Health)
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All rights reserved