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Biparental inheritance of mitochondrial DNA revisited.

Accepted version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/322454

Repository DOI

https://doi.org/10.17863/CAM.69912
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Accepted version (71.31 KB)

Type

Article

Change log

Authors

Pagnamenta, Alistair T  ORCID logo  https://orcid.org/0000-0001-7334-0602
Wei, Wei  ORCID logo  https://orcid.org/0000-0002-2945-3543
Rahman, Shamima  ORCID logo  https://orcid.org/0000-0003-2088-730X
Chinnery, Patrick F  ORCID logo  https://orcid.org/0000-0002-7065-6617

Abstract

Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA and highlight the co-amplification of rare, concatenated nuclear mtDNA segments as a technical artefact that may explain previous observations.

Description

Keywords

DNA, Mitochondrial, Humans, Maternal Inheritance, Paternal Inheritance

Journal Title

Nat Rev Genet

Conference Name

Journal ISSN

1471-0056
1471-0064

Volume Title

22

Publisher

Springer Nature

Publisher DOI

https://doi.org/10.1038/s41576-021-00380-6

Rights and licensing

All rights reserved
Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Wellcome Trust (212219/Z/18/Z)
Medical Research Council (MC_UU_00015/7)

Collections

University of Cambridge Research Outputs (Articles and Conferences)