Electrotherapies for Glioblastoma.
Jenkins, Elise PW
Triantis, Iasonas F
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wiley Open Access
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Jenkins, E. P., Finch, A., Gerigk, M., Triantis, I. F., Watts, C., & Malliaras, G. (2021). Electrotherapies for Glioblastoma.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2100978. https://doi.org/10.1002/advs.202100978
Non-thermal, intermediate frequency (100-500 kHz) electrotherapies present a unique therapeutic strategy to treat malignant neoplasms. Here, we review pulsed electric fields which induce reversible or irreversible electroporation and tumour-treating fields highlighting the foundations, advances and considerations of each method specifically when applied to glioblastoma multiforme. We describe several biological aspects of glioblastomas that contribute to treatment complexity (including heterogeneity, recurrence, resistance and blood-brain barrier) and electrophysiological traits which are suggested to promote glioma progression. In particular, we describe the biological responses at the cellular and molecular level to specific parameters of the electrical stimuli offering ways to compare these parameters despite the lack of a universally adopted physical description. Reviewing the literature, we find a disconnect between electrotherapy techniques and how they target the biological complexities of glioblastoma that make treatment difficult in the first place. We attempt to bridge the interdisciplinary gap by mapping biological characteristics to different methods of electrotherapy, suggesting important future research topics and directions in both understanding and treating glioblastoma. To our knowledge, this is the first paper that attempts an in-tandem assessment of the biological effects of different aspects of intermediate frequency electrotherapy methods, thus offering possible strategies towards glioblastoma treatment.
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External DOI: https://doi.org/10.1002/advs.202100978
This record's URL: https://www.repository.cam.ac.uk/handle/1810/323602
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