Gene duplication and subsequent diversification strongly affect phenotypic evolvability and robustness.
Royal Society open science
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Jouffrey, V., Leonard, A., & Ahnert, S. (2021). Gene duplication and subsequent diversification strongly affect phenotypic evolvability and robustness.. Royal Society open science, 8 (6), 201636. https://doi.org/10.1098/rsos.201636
We study the effects of non-determinism and gene duplication on the structure of genotype-phenotype maps by introducing a non-deterministic version of the Polyomino self-assembly model. This model has previously been used in a variety of contexts to model the assembly and evolution of protein quaternary structure. Firstly we show the limit of the current deterministic paradigm which leads to built-in anti-correlation between evolvability and robustness at the genotypic level. We develop a set of metrics to measure structural properties of genotype-phenotype maps in a non-deterministic setting and use them to evaluate the effects of gene duplication and subsequent diversification. Our generalised versions of evolvability and robustness exhibit positive correlation for a subset of genotypes. This positive correlation is only possible because non-deterministic phenotypes can contribute to both robustness and evolvability. Secondly we show that duplication increases robustness and reduces evolvability initially, but that the subsequent diversification that duplication enables has a stronger, inverse effect, greatly increasing evolvability and reducing robustness relative to their original values.
Gatsby Charitable Foundation (GAT3395/CCD)
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External DOI: https://doi.org/10.1098/rsos.201636
This record's URL: https://www.repository.cam.ac.uk/handle/1810/323697
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