Thiazole formation through a modified Gewald reaction.
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Abstract
The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.
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Beilstein J Org Chem
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1860-5397
1860-5397
1860-5397
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11
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Beilstein Institut
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Except where otherwised noted, this item's license is described as Attribution 4.0 International