Autophagy in healthy ageing and disease
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Rubinsztein, D., & Fang, E. Autophagy in healthy ageing and disease. Nature Aging https://doi.org/10.17863/CAM.72577
Autophagy is a fundamental cellular process that eliminates subcellular components via lysosome mediated degradation to promote homeostasis, differentiation, development, and survival. While autophagy is intimately linked to health, the intricate relationship between autophagy, ageing and disease, remains unclear. Furthermore, the broad spectrum of substrates associated with autophagy (nucleic acids, proteins, lipids, organelles, and pathogens) raises a key question: how do distinct autophagic mechanisms influence tissue and organismal homeostasis in the long-term? This review examines several emerging features of autophagy and postulates how they may be linked to ageing as well as to the development and progression of disease. In addition, we discuss the current pre-clinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies, such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of ageing. Understanding the precise interplay between functionally active autophagy and the risk of age-related pathologies will elucidate the ageing landscape across organisms and eventually facilitate the development of clinical applications that promote long-term health.
D.C.R. is supported by the UK Dementia Research Institute (funded by the MRC, Alzheimer’s Research UK and the Alzheimer’s Society) (UKDRI-2002 to DCR), The Tau Consortium, Alzheimer’s Research UK, an anonymous donation to the Cambridge Centre for Parkinson-Plus, and The Roger de Spoelberch Prize.
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This record's DOI: https://doi.org/10.17863/CAM.72577
This record's URL: https://www.repository.cam.ac.uk/handle/1810/325121
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