Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes.
View / Open Files
Christensen, Dirk L
Nature Publishing Group
MetadataShow full item record
Gonzales, T., Westgate, K., Strain, T., Hollidge, S., Jeon, J., Christensen, D. L., Jensen, J., et al. (2021). Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes.. Scientific reports, 11 (1), 15315. https://doi.org/10.1038/s41598-021-94768-3
Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from heart rate response to low-risk personalised exercise tests. We apply the method to examine associations between CRF and health outcomes in the UK Biobank study, one of the world’s largest and most inclusive studies of CRF, showing that risk of all-cause mortality is 8% lower (95%CI 5-11%, 2,670 deaths among 79,981 participants) and cardiovascular mortality is 9% lower (95%CI 4-14%, 854 deaths) per 1-metabolic equivalent difference in CRF. Associations obtained with the novel validated CRF estimation method are stronger than those obtained using previous methodology, suggesting previous methods may have underestimated the importance of fitness for human health
This work was funded by the UK Medical Research Council (MC_UU_12015/3 and MC_UU_00006/4) and the NIHR Biomedical Research Centre in Cambridge (IS-BRC-1215-20014). UK Biobank is acknowledged for contributing to the costs of the validation fieldwork. The funders had no role in the design, conduct, analysis, and decision to publish results from this study.
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Embargo Lift Date
External DOI: https://doi.org/10.1038/s41598-021-94768-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/325223
All rights reserved