Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Alexander, Laith
Banai-Tizkar, Rana
Wood, Christian M
Roberts, Angela C
Abstract
Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, Callithrix jacchus, on an appetitive Pavlovian conditioning paradigm to measure behavioral and cardiovascular correlates of anticipatory and consummatory phases of reward processing. We describe how to use intracerebral infusions to manipulate brain regions whose activity is relevant to impaired reward processing in depression and how the paradigm can be used to test antidepressant efficacy. For complete details on the use and execution of this protocol, please refer to Alexander et al. (2019).
Description
Keywords
Behavior, Model Organisms, Neuroscience, Anhedonia, Animals, Brain, Callithrix, Conditioning, Classical, Disease Models, Animal
Journal Title
STAR Protoc
Conference Name
Journal ISSN
2666-1667
2666-1667
2666-1667
Volume Title
2
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (108089/Z/15/Z)