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The geometry of rest–spike bistability

Published version
Peer-reviewed

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Authors

Cirillo, Giuseppe Ilario  ORCID logo  https://orcid.org/0000-0002-1162-3225
Sepulchre, Rodolphe 

Abstract

Abstract: Morris–Lecar model is arguably the simplest dynamical model that retains both the slow–fast geometry of excitable phase portraits and the physiological interpretation of a conductance-based model. We augment this model with one slow inward current to capture the additional property of bistability between a resting state and a spiking limit cycle for a range of input current. The resulting dynamical system is a core structure for many dynamical phenomena such as slow spiking and bursting. We show how the proposed model combines physiological interpretation and mathematical tractability and we discuss the benefits of the proposed approach with respect to alternative models in the literature.

Description

Funder: Qualcomm; doi: http://dx.doi.org/10.13039/100005144

Keywords

Research, Rest–spike bistability, Neuronal models, Slow–fast models

Journal Title

The Journal of Mathematical Neuroscience

Conference Name

Journal ISSN

2190-8567

Volume Title

10

Publisher

Springer Berlin Heidelberg
Sponsorship
Engineering and Physical Sciences Research Council (RG80792)
European Research Council (670645)