TMED9-SEC12, an important "contact" for autophagy.
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Abstract
Autophagosome biogenesis occurs via a complex mechanism that involves membranes from different subcellular compartments. Here, we review an elegant study from Li et al. describing a new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that leads to the formation of COPII-coated vesicles essential for the formation of the autophagosome, and attempt to reconcile their findings with our studies proposing that the recycling endosome is a core platform for autophagosome biogenesis.
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Cell Res
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1001-0602
1748-7838
1748-7838
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Springer Nature
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UK Dementia Research Institute (funded by MRC, Alzheimer’s Research UK and the Alzheimer’s Society).