Atypical genomic cortical patterning in autism with poor early language outcome.
Gazestani, Vahid H
Hagler, Donald J
American Association for the Advancement of Science (AAAS)
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Lombardo, M. V., Eyler, L., Pramparo, T., Gazestani, V. H., Hagler, D. J., Chen, C., Dale, A. M., et al. (2021). Atypical genomic cortical patterning in autism with poor early language outcome.. Sci Adv, 7 (36) https://doi.org/10.1126/sciadv.abh1663
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here, we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT), present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by a secondary and independent genomic patterning effect on CT. Genes involved in these effects can be traced back to midgestational A-P and D-V gene expression gradients and different prenatal cell types (e.g., progenitor cells and excitatory neurons), are functionally important for vocal learning and human-specific evolution, and are prominent in prenatal coexpression networks enriched for high-penetrance autism risk genes. Autism with poor early language outcome may be explained by atypical genomic cortical patterning starting in prenatal development, which may detrimentally affect later regional functional specialization and circuit formation.
Medical Research Council (MR/M009041/1)
External DOI: https://doi.org/10.1126/sciadv.abh1663
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329523
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/