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dc.contributor.authorHerzog, Rubén
dc.contributor.authorMediano, Pedro A. M.
dc.contributor.authorRosas, Fernando E.
dc.contributor.authorCarhart-Harris, Robin
dc.contributor.authorPerl, Yonatan Sanz
dc.contributor.authorTagliazucchi, Enzo
dc.contributor.authorCofre, Rodrigo
dc.date.accessioned2021-10-20T15:23:12Z
dc.date.available2021-10-20T15:23:12Z
dc.date.issued2020-10-20
dc.date.submitted2020-05-25
dc.identifier.others41598-020-74060-6
dc.identifier.other74060
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329673
dc.descriptionFunder: Ad Astra Chandaria Foundation
dc.description.abstractAbstract: Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/378/116/2392
dc.subject/631/154/436/2388
dc.subject/631/114/2397
dc.subject/631/378/2649/1398
dc.subjectarticle
dc.titleA mechanistic model of the neural entropy increase elicited by psychedelic drugs
dc.typeArticle
dc.date.updated2021-10-20T15:23:10Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume10
dc.identifier.doi10.17863/CAM.77120
dcterms.dateAccepted2020-09-24
rioxxterms.versionofrecord10.1038/s41598-020-74060-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2045-2322
pubs.funder-project-idComisión Nacional de Investigación Científica y Tecnológica (2018-21180428, PAI 79160120)
pubs.funder-project-idWellcome Trust (210920/Z/18/Z)
pubs.funder-project-idFondo Nacional de Desarrollo Científico y Tecnológico (11181072)


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