Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat
Authors
Alexander, Laith
Sawiak, Stephen J.
Fryer, Tim D.
Hong, Young T.
McIver, Lauren
Clarke, Hannah F.
Publication Date
2020-10-26Journal Title
Nature Communications
Publisher
Nature Publishing Group UK
Volume
11
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Alexander, L., Wood, C. M., Gaskin, P. L. R., Sawiak, S. J., Fryer, T. D., Hong, Y. T., McIver, L., et al. (2020). Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat. Nature Communications, 11 (1) https://doi.org/10.1038/s41467-020-19167-0
Abstract
Abstract: Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25) has been implicated in these illnesses, it is unknown whether this over-activity is causal. By combining targeted intracerebral microinfusions with cardiovascular and behavioral monitoring in marmosets, we show that over-activation of sgACC/25 reduces vagal tone and heart rate variability, alters cortisol dynamics during stress and heightens reactivity to proximal and distal threat. 18F-FDG PET imaging shows these changes are accompanied by altered activity within a network of brain regions including the amygdala, hypothalamus and dorsolateral prefrontal cortex. Ketamine, shown to have rapid antidepressant effects, fails to reverse elevated arousal to distal threat contrary to the beneficial effects we have previously demonstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its actions.
Keywords
Article, /631/378/1689/1300, /631/378/1689/1414, /631/378/1689/1831, /631/378/1457/1601, /631/378/1457/1945, /59/78, /64, /59, article
Sponsorship
Wellcome Trust (Wellcome) (108089/Z/15/Z)
Identifiers
s41467-020-19167-0, 19167
External DOI: https://doi.org/10.1038/s41467-020-19167-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329977
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk