The neurological sequelae of pandemics and epidemics
Publication Date
2020-10-26Journal Title
Journal of Neurology
ISSN
0340-5354
Publisher
Springer Berlin Heidelberg
Volume
268
Issue
8
Pages
2629-2655
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Valerio, F., Whitehouse, D. P., Menon, D. K., & Newcombe, V. F. J. (2020). The neurological sequelae of pandemics and epidemics. Journal of Neurology, 268 (8), 2629-2655. https://doi.org/10.1007/s00415-020-10261-3
Description
Funder: NIHR Cambridge Biomedical Research Centre (GB)
Funder: University of Cambridge
Abstract
Abstract: Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestations may lead to an increase in the burden of acute disease as well as secondary complications with long-term consequences. Nervous system infection or dysfunction during pandemics is common and its enduring consequences, especially among vulnerable populations, are frequently forgotten. An improved understanding the possible mechanisms of neurological damage during epidemics, and increased recognition of the possible manifestations is fundamental to bring insights when dealing with future outbreaks. To reverse this gap in knowledge, we reviewed all the pandemics, large and important epidemics of human history in which neurological manifestations are evident, and described the possible physiological processes that leads to the adverse sequelae caused or triggered by those pathogens.
Keywords
Review, COVID-19, CNS infections, Peripheral neuropathies, Pandemics/history, Meningitis, Encephalitis
Identifiers
s00415-020-10261-3, 10261
External DOI: https://doi.org/10.1007/s00415-020-10261-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/329978
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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