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dc.contributor.authorAlzamil, Lama
dc.contributor.authorNikolakopoulou, Konstantina
dc.contributor.authorTurco, Margherita Y.
dc.date.accessioned2021-11-01T16:26:34Z
dc.date.available2021-11-01T16:26:34Z
dc.date.issued2020-06-03
dc.date.submitted2020-02-04
dc.identifier.issn1350-9047
dc.identifier.others41418-020-0565-5
dc.identifier.other565
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330141
dc.descriptionFunder: Centre for Trophoblast Research L'Oreal Women in Science Fellowship
dc.description.abstractAbstract: Both the proper functioning of the female reproductive tract (FRT) and normal placental development are essential for women’s health, wellbeing, and pregnancy outcome. The study of the FRT in humans has been challenging due to limitations in the in vitro and in vivo tools available. Recent developments in 3D organoid technology that model the different regions of the FRT include organoids of the ovaries, fallopian tubes, endometrium and cervix, as well as placental trophoblast. These models are opening up new avenues to investigate the normal biology and pathology of the FRT. In this review, we discuss the advances, potential, and limitations of organoid cultures of the human FRT.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectReview Article
dc.subject/631/80
dc.subject/631/443
dc.subject/692/699
dc.subject/13
dc.subject/13/107
dc.subject/38
dc.subject/13/100
dc.subject/13/106
dc.subjectreview-article
dc.titleOrganoid systems to study the human female reproductive tract and pregnancy
dc.typeArticle
dc.date.updated2021-11-01T16:26:33Z
prism.endingPage51
prism.issueIdentifier1
prism.publicationNameCell Death & Differentiation
prism.startingPage35
prism.volume28
dc.identifier.doi10.17863/CAM.77583
dcterms.dateAccepted2020-05-15
rioxxterms.versionofrecord10.1038/s41418-020-0565-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidTurco, Margherita Y. [0000-0002-3380-7375]
dc.identifier.eissn1476-5403
pubs.funder-project-idRoyal Society (DH160216)
pubs.funder-project-idIsaac Newton Trust (G100391)
pubs.funder-project-idEC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) (853546)
pubs.funder-project-idKing Saud University (KSU) (KSU1520)
pubs.funder-project-idWellcome Trust (Wellcome) (UNS13724)


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