Helicobacter pylori's historical journey through Siberia and the Americas.
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Authors
Brunelli, Andrea
Zhou, Zhemin
Linz, Bodo
Publication Date
2021-06-22Journal Title
Proc Natl Acad Sci U S A
ISSN
0027-8424
Publisher
Proceedings of the National Academy of Sciences
Volume
118
Issue
25
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print
Metadata
Show full item recordCitation
Moodley, Y., Brunelli, A., Ghirotto, S., Klyubin, A., Maady, A. S., Tyne, W., Muñoz-Ramirez, Z. Y., et al. (2021). Helicobacter pylori's historical journey through Siberia and the Americas.. Proc Natl Acad Sci U S A, 118 (25) https://doi.org/10.1073/pnas.2015523118
Abstract
The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait.
Keywords
Americas, Helicobacter pylori, Siberia, colonization, demographic model, Americas, Animal Migration, Biological Evolution, Genome, Bacterial, Geography, Helicobacter pylori, Humans, Models, Biological, Multilocus Sequence Typing, Siberia
Identifiers
External DOI: https://doi.org/10.1073/pnas.2015523118
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330521
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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