The IUPHAR/BPS Guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials
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Authors
Harding, Simon
Armstrong, Jane
Faccenda, Elena
Southan, Christopher
Alexander, Stephen
Pawson, Adam
Spedding, Michael
Davies, Jamie
Journal Title
Nucleic Acids Research
ISSN
0305-1048
Publisher
Oxford University Press
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Harding, S., Armstrong, J., Faccenda, E., Southan, C., Alexander, S., Davenport, A., Pawson, A., et al. (2021). The IUPHAR/BPS Guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials. Nucleic Acids Research https://doi.org/10.1093/nar/gkab1010
Abstract
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (https://www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.
Sponsorship
I am a contributing author. Open Access CC-BY is funded by the University of Edinburgh Wellcome Trust Institutional Strategic Support Fund. The manuscript has a statement:
For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Identifiers
External DOI: https://doi.org/10.1093/nar/gkab1010
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331071
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