The role of prefrontal cortex in cognitive control and executive function.
Springer Science and Business Media LLC
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Friedman, N. P., & Robbins, T. (2022). The role of prefrontal cortex in cognitive control and executive function.. Neuropsychopharmacology, 47 (1), 72-89. https://doi.org/10.1038/s41386-021-01132-0
Funder: U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
Funder: National Research Foundation (Singapore) CREATE Grant to the University of Cambridge and Nanyang Technological University for the Centre of Lifelong Learning and Individualised Cognition (CLIC).
Concepts of cognitive control (CC) and executive function (EF) are defined in terms of their relationships with goal-directed behavior versus habits and controlled versus automatic processing, and related to the functions of the prefrontal cortex (PFC) and related regions and networks. A psychometric approach shows unity and diversity in CC constructs, with 3 components in the most commonly studied constructs: general or common CC and components specific to mental set shifting and working memory updating. These constructs are considered against the cellular and systems neurobiology of PFC and what is known of its functional neuroanatomical or network organization based on lesioning, neurochemical, and neuroimaging approaches across species. CC is also considered in the context of motivation, as "cool" and "hot" forms. Its Common CC component is shown to be distinct from general intelligence (g) and closely related to response inhibition. Impairments in CC are considered as possible causes of psychiatric symptoms and consequences of disorders. The relationships of CC with the general factor of psychopathology (p) and dimensional constructs such as impulsivity in large scale developmental and adult populations are considered, as well as implications for genetic studies and RDoC approaches to psychiatric classification.
Review Article, /631/378/2649/2150, /631/477/2811, /692/699/476, review-article
U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) (DA046413, DA042742, DA051018)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) (MH117131)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) (AG046938)
External DOI: https://doi.org/10.1038/s41386-021-01132-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331440