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dc.contributor.authorElshina, Elizaveta
dc.contributor.authorTe Velthuis, Aartjan JW
dc.date.accessioned2021-12-15T11:10:49Z
dc.date.available2021-12-15T11:10:49Z
dc.date.issued2021-12
dc.date.submitted2021-06-09
dc.identifier.issn1420-682X
dc.identifier.others00018-021-03957-w
dc.identifier.other3957
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331467
dc.description.abstractInfluenza A viruses cause a mild-to-severe respiratory disease that affects millions of people each year. One of the many determinants of disease outcome is the innate immune response to the viral infection. While antiviral responses are essential for viral clearance, excessive innate immune activation promotes lung damage and disease. The influenza A virus RNA polymerase is one of viral proteins that affect innate immune activation during infection, but the mechanisms behind this activity are not well understood. In this review, we discuss how the viral RNA polymerase can both activate and suppress innate immune responses by either producing immunostimulatory RNA species or directly targeting the components of the innate immune signalling pathway, respectively. Furthermore, we provide a comprehensive overview of the polymerase residues, and their mutations, associated with changes in innate immune activation, and discuss their putative effects on polymerase function based on recent advances in our understanding of the influenza A virus RNA polymerase structure.
dc.description.sponsorshipEngineering and Physical Sciences Research Council scholarship EP/ S515322/1 National Institutes of Health grant R21AI147172
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectReview
dc.subjectRIG-I
dc.subjectmvRNA
dc.subjectDVG
dc.subjectRdRp
dc.subjectInnate immune response
dc.subjectPB1
dc.subjectPB2
dc.subjectPA
dc.subjectIFN
dc.titleThe influenza virus RNA polymerase as an innate immune agonist and antagonist.
dc.typeArticle
dc.date.updated2021-12-15T11:10:48Z
prism.endingPage7256
prism.issueIdentifier23
prism.publicationNameCell Mol Life Sci
prism.startingPage7237
prism.volume78
dc.identifier.doi10.17863/CAM.78921
dcterms.dateAccepted2021-09-29
rioxxterms.versionofrecord10.1007/s00018-021-03957-w
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidElshina, Elizaveta [0000-0001-9377-5363]
dc.contributor.orcidTe Velthuis, Aartjan JW [0000-0002-5129-3953]
dc.identifier.eissn1420-9071
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/S515322/1)
pubs.funder-project-idNational Institutes of Health (NIH) (1R21AI147172-01)
pubs.funder-project-idWellcome Trust (206579/Z/17/Z)
cam.issuedOnline2021-10-22


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