Lipotoxicity: a driver of heart failure with preserved ejection fraction?
Clinical science (London, England : 1979)
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Leggat, J., Bidault, G., & Vidal-Puig, A. (2021). Lipotoxicity: a driver of heart failure with preserved ejection fraction?. Clinical science (London, England : 1979), 135 (19), 2265-2283. https://doi.org/10.1042/CS20210127
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern, with rising incidence alongside high morbidity and mortality. However, the pathophysiology of HFpEF is not yet fully understood. The association between HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid accumulation and subsequent lipotoxicity.
diastolic dysfunction, heart failure with preserved ejection fraction, lipid metabolism, lipotoxicity, metabolic syndrome
We thank the British Heart Foundation [grant numbers RG/18/7/33636 and FS/17/61/33473]; the Cambridge BHF Centre of Research Excellence [grant number RE/18/1/34212]; and the Medical Research Council [grant number MC UU 12012/2] for funding this work.
Medical Research Council (MC_UU_12012/2)
British Heart Foundation (RG/18/7/33636)
British Heart Foundation (FS/17/61/33473D)
British Heart Foundation (RE/18/1/34212)
Medical Research Council (G0802051)
Medical Research Council (G0400192)
British Heart Foundation (None)
Medical Research Council (MC_UU_12012/5)
External DOI: https://doi.org/10.1042/CS20210127
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331608
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/