The dynamics of mitochondrial autophagy at the initiation stage.

Authors
Ktistakis, Nicholas T  ORCID logo  https://orcid.org/0000-0001-9397-2914

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Article
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Abstract

The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed on the earliest steps of the pathway concerning the mechanisms and requirements for initiating autophagosome formation on a mitochondrial target. More specifically, and in view of the fact that we understand the basic mechanism of non-selective autophagy and are beginning to reshape this knowledge towards the pathways of selective autophagy, two aspects of mitophagy will be covered: (i) How does a machinery normally working in association with the endoplasmic reticulum (ER) to make an autophagosome can also do so at a site distinct from the ER such as on the surface of the targeted cargo? and (ii) how does the machinery deal with cargo of multiple sizes?

Publication Date
2021-11-01
Online Publication Date
2021-10-19
Acceptance Date
2021-10-01
Keywords
autophagy, endoplasmic reticulum, imaging techniques, mitochondria, Autophagosomes, Endoplasmic Reticulum, Humans, Ivermectin, Mitochondria, Mitophagy
Journal Title
Biochem Soc Trans
Journal ISSN
0300-5127
1470-8752
Volume Title
49
Publisher
Portland Press Ltd.