The dynamics of mitochondrial autophagy at the initiation stage.
Biochem Soc Trans
Portland Press Ltd.
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Ktistakis, N. T. (2021). The dynamics of mitochondrial autophagy at the initiation stage.. Biochem Soc Trans, 49 (5), 2199-2210. https://doi.org/10.1042/BST20210272
The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed on the earliest steps of the pathway concerning the mechanisms and requirements for initiating autophagosome formation on a mitochondrial target. More specifically, and in view of the fact that we understand the basic mechanism of non-selective autophagy and are beginning to reshape this knowledge towards the pathways of selective autophagy, two aspects of mitophagy will be covered: (i) How does a machinery normally working in association with the endoplasmic reticulum (ER) to make an autophagosome can also do so at a site distinct from the ER such as on the surface of the targeted cargo? and (ii) how does the machinery deal with cargo of multiple sizes?
autophagy, endoplasmic reticulum, imaging techniques, mitochondria
External DOI: https://doi.org/10.1042/BST20210272
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331762
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/