The dynamics of mitochondrial autophagy at the initiation stage.
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Authors
Publication Date
2021-11-01Journal Title
Biochem Soc Trans
ISSN
0300-5127
Publisher
Portland Press Ltd.
Volume
49
Issue
5
Pages
2199-2210
Type
Article
This Version
VoR
Physical Medium
Print
Metadata
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Ktistakis, N. (2021). The dynamics of mitochondrial autophagy at the initiation stage.. Biochem Soc Trans, 49 (5), 2199-2210. https://doi.org/10.1042/BST20210272
Abstract
The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed on the earliest steps of the pathway concerning the mechanisms and requirements for initiating autophagosome formation on a mitochondrial target. More specifically, and in view of the fact that we understand the basic mechanism of non-selective autophagy and are beginning to reshape this knowledge towards the pathways of selective autophagy, two aspects of mitophagy will be covered: (i) How does a machinery normally working in association with the endoplasmic reticulum (ER) to make an autophagosome can also do so at a site distinct from the ER such as on the surface of the targeted cargo? and (ii) how does the machinery deal with cargo of multiple sizes?
Keywords
autophagy, endoplasmic reticulum, imaging techniques, mitochondria
Identifiers
External DOI: https://doi.org/10.1042/BST20210272
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331762
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