Prevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020.
Authors
Siller, Anita
Wachter, Gregor A
Neururer, Sabrina
Pfeifer, Bernhard
Astl, Manfred
Borena, Wegene
Kimpel, Janine
Elmer, Sebastian
Spöck, Franziska
Vales, Anja
Mühlbacher, Annelies
Gaber, Manfred
Schennach, Harald
Publication Date
2021-12Journal Title
Wien Klin Wochenschr
ISSN
0043-5325
Publisher
Springer Science and Business Media LLC
Volume
133
Issue
23-24
Pages
1272-1280
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Siller, A., Wachter, G. A., Neururer, S., Pfeifer, B., Astl, M., Borena, W., Kimpel, J., et al. (2021). Prevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020.. Wien Klin Wochenschr, 133 (23-24), 1272-1280. https://doi.org/10.1007/s00508-021-01963-3
Description
Funder: tirol kliniken gmbh
Funder: University of Innsbruck and Medical University of Innsbruck
Abstract
BACKGROUND: Seroepidemiological studies provide important insight into the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) in our society. We aimed to determine seropositivity of SARS-CoV‑2 antibodies and its cross-sectional correlates in a large cohort of blood donors. METHODS: In this observational cohort study, we tested healthy blood donors residing in Tyrol, Austria, for SARS-CoV‑2 antibodies using the Abbott SARS-CoV‑2 IgG chemiluminescent microparticle immunoassay. We estimated 95% confidence intervals (95% CI) of seroprevalences using bootstrapping and tested for differences by participant characteristics using logistic regression. FINDINGS: Between 8 June and 4 September 2020, we screened 5345 healthy individuals at local blood donor sessions (mean age 42.7 years, SD 13.5 years, 46.7% female). Overall seroprevalence was 3.1% (95% CI 2.7-3.6%, 165 cases), which is 5.1-fold higher (95% CI 4.5-6.0%) than the case number identified by the health authorities in the state-wide testing program (0.6%; 4536 out of 757,634). Seroprevalence was higher in the district Landeck (16.6%, P < 0.001) and in individuals aged < 25 years (4.7%, P = 0.043), but did not differ by gender, blood types, or medication intake. The odds ratio for seropositivity was 2.51 for participants who had travelled to Ischgl (1.49-4.21, P = 0.001), 1.39 who had travelled to other federal states (1.00-1.93, P = 0.052), and 2.41 who had travelled abroad (1.61-3.63, P < 0.001). Compared to participants who had a suspected/confirmed SARS-CoV‑2 infection but were seronegative, seropositive participants more frequently reported loss of smell (odds ratio = 2.49, 1.32-4.68, P = 0.005) and taste (odds ratio = 2.76, 1.54-4.92, P = 0.001). CONCLUSION: In summer 2020, SARS-CoV‑2 seroprevalence in Tyrolean blood donors was 3.1%. Our study revealed regional variation and associations with young age, travel history and specific symptoms.
Keywords
Original Article, Seropositivity, Covid-19, Epidemiology, Seroprevalence, Cross-sectional studies
Identifiers
s00508-021-01963-3, 1963
External DOI: https://doi.org/10.1007/s00508-021-01963-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/331901
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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