Oxygen regulation of TET enzymes.
Publication Date
2021-12Journal Title
FEBS J
ISSN
1742-464X
Publisher
Wiley
Volume
288
Issue
24
Pages
7143-7161
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Matuleviciute, R., Cunha, P. P., Johnson, R. S., & Foskolou, I. P. (2021). Oxygen regulation of TET enzymes.. FEBS J, 288 (24), 7143-7161. https://doi.org/10.1111/febs.15695
Abstract
Hypoxia has a significant impact on many physiological and pathological processes. Over the recent years, its role in modulation of epigenetic remodelling has also become clearer. In cancer, low oxygen environments and aberrant epigenomes often go hand in hand, and changes in DNA methylation are now commonly recognised as potential outcome indicators. TET (ten-eleven translocation) family enzymes are alpha-ketoglutarate-, iron- and oxygen-dependent DNA demethylases and are key players in these processes. Although TETs have historically been considered tumour suppressors, recent studies suggest that their functions in cancer might not be straightforward. Recently, inhibition of TETs has been reported to have positive impact in cancer immunotherapy and vaccination studies. This underlines the current interest in developing targeted pharmaceutical inhibitors of these enzymes. Here, we will survey the complexity of TET roles in cancer, and its hypoxic modulation, as well as highlight the potential of these enzymes as therapeutic targets.
Keywords
5hmC, TET, cancer, hypoxia, immunotherapy, α-KG-dependent enzymes, Animals, Humans, Mixed Function Oxygenases, Neoplasms, Oxygen
Sponsorship
Wellcome Trust (214283/Z/18/Z)
Identifiers
febs15695
External DOI: https://doi.org/10.1111/febs.15695
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332049
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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