The Pupillary Light Reflex as a Biomarker of Concussion.
Azzolino, Sergio F
D'Arcy, Ryan CN
MetadataShow full item record
Carrick, F. R., Azzolino, S. F., Hunfalvay, M., Pagnacco, G., Oggero, E., D'Arcy, R. C., Abdulrahman, M., & et al. (2021). The Pupillary Light Reflex as a Biomarker of Concussion.. Life (Basel) https://doi.org/10.3390/life11101104
The size of our pupils changes continuously in response to variations in ambient light levels, a process known as the pupillary light reflex (PLR). The PLR is not a simple reflex as its function is modulated by cognitive brain function and any long-term changes in brain function secondary to injury should cause a change in the parameters of the PLR. We performed a retrospective clinical review of the PLR of our patients using the BrightLamp Reflex iPhone app. The PLR variables of latency, maximum pupil diameter (MaxPD), minimum pupil diameter (MinPD), maximum constriction velocity (MCV), and the 75% recovery time (75% PRT) were associated with significant differences between subjects who had suffered a concussion and those that had not. There were also significant differences in PLR metrics over the life span and between genders and those subjects with and without symptoms. The differences in PLR metrics are modulated not only by concussion history but also by gender and whether or not the person has symptoms associated with a head injury. A concussive injury to the brain is associated with changes in the PLR that persist over the life span, representing biomarkers that might be used in clinical diagnosis, treatment, and decision making.
brain function, concussion, gender difference, pupil light reflex, pupillometry
External DOI: https://doi.org/10.3390/life11101104
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332160
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: email@example.com