Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.
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Authors
Barnett, Jennifer
Lindberg, Nina
Lahdensuo, Kaisla
Kieseppä, Tuula
Jukuri, Tuomas
Cederlöf, Erik
Wegelius, Asko
Männynsalo, Teemu
Niemi-Pynttäri, Jussi
Lönnqvist, Jouko
Publication Date
2021-10-27Journal Title
Brain Sci
ISSN
2076-3425
Publisher
MDPI AG
Volume
11
Issue
11
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Mazumder, A. H., Barnett, J., Isometsä, E. T., Lindberg, N., Torniainen-Holm, M., Lähteenvuo, M., Lahdensuo, K., et al. (2021). Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.. Brain Sci, 11 (11) https://doi.org/10.3390/brainsci11111422
Abstract
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
Keywords
Schizophrenia, Cognition, Reaction time, Bipolar disorder, Hazardous Drinking, Schizoaffective Disorder, Visual Memory, Pgs
Sponsorship
The the Iso-Mällisen Foundation (Iso-Mällisen Säätiö) (0400 584622)
The Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (6045290-5500000710 and 6000009-5500000710)
The H2020 Marie Skłodowska-Curie Actions co-funding of regional, national, and international pro-grams (COFUND) (713606)
Identifiers
PMC8615595, 34827421
External DOI: https://doi.org/10.3390/brainsci11111422
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332439
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