The Energy Landscape Perspective: Encoding Structure and Function for Biomolecules.
Wales, David J
Front Mol Biosci
MetadataShow full item record
Röder, K., & Wales, D. J. (2022). The Energy Landscape Perspective: Encoding Structure and Function for Biomolecules.. Front Mol Biosci https://doi.org/10.3389/fmolb.2022.820792
The energy landscape perspective is outlined with particular reference to biomolecules that perform multiple functions. We associate these multifunctional molecules with multifunnel energy landscapes, illustrated by some selected examples, where understanding the organisation of the landscape has provided new insight into function. Conformational selection and induced fit may provide alternative routes to realisation of multifunctionality, exploiting the possibility of environmental control and distinct binding modes.
biomolecules, disorder, energy landscapes, folding, multiple functions, structural heterogeneity
Cambridge Philosophical Society EPSRC
Engineering and Physical Sciences Research Council (EP/N035003/1)
External DOI: https://doi.org/10.3389/fmolb.2022.820792
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332597
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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