The Energy Landscape Perspective: Encoding Structure and Function for Biomolecules.
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Authors
Röder, Konstantin
Wales, David J
Publication Date
2022Journal Title
Front Mol Biosci
ISSN
2296-889X
Publisher
Frontiers Media
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Röder, K., & Wales, D. J. (2022). The Energy Landscape Perspective: Encoding Structure and Function for Biomolecules.. Front Mol Biosci https://doi.org/10.3389/fmolb.2022.820792
Abstract
The energy landscape perspective is outlined with particular reference to biomolecules that perform multiple functions. We associate these multifunctional molecules with multifunnel energy landscapes, illustrated by some selected examples, where understanding the organisation of the landscape has provided new insight into function. Conformational selection and induced fit may provide alternative routes to realisation of multifunctionality, exploiting the possibility of environmental control and distinct binding modes.
Keywords
biomolecules, disorder, energy landscapes, folding, multiple functions, structural heterogeneity
Sponsorship
Cambridge Philosophical Society
EPSRC
Funder references
Engineering and Physical Sciences Research Council (EP/N035003/1)
Identifiers
External DOI: https://doi.org/10.3389/fmolb.2022.820792
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332597
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