The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.

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Authors
Yura, Yoshimitsu
  Miura-Yura, Emiri
Katanasaka, Yasufumi
Min, Kyung-Duk
  Chavkin, Nicholas
Polizio, Ariel H
Ogawa, Hayato
Publication Date
2021-09-03
Journal Title
Circ Res
ISSN
0009-7330
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
129
Issue
6
Pages
684-698
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
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Citation
Yura, Y., Miura-Yura, E., Katanasaka, Y., Min, K., Chavkin, N., Polizio, A. H., Ogawa, H., et al. (2021). The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice.. Circ Res, 129 (6), 684-698. https://doi.org/10.1161/CIRCRESAHA.121.319314
Abstract
[Figure: see text].
Keywords
CRISPR-Cas Systems, DNA damage, cardiotoxicity, clonal hematopoiesis, heart failure, inflammasome, macrophages, Angiotensin II, Animals, Clonal Hematopoiesis, DNA Damage, Gain of Function Mutation, Heart Failure, Hematopoietic Stem Cells, Inflammasomes, Interleukin-18, Interleukin-1beta, Macrophages, Male, Mice, Mice, Inbred C57BL, NLR Family, Pyrin Domain-Containing 3 Protein, Protein Phosphatase 2C
Sponsorship
Medical Research Council (MC_PC_17230)
Identifiers
External DOI: https://doi.org/10.1161/CIRCRESAHA.121.319314
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332738
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International