A role for CUX1 in the regulation of p16 and senescence.
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Abstract
Vascular senescence has been implicated in atherosclerosis. By characterizing SNPs in the p16-encoding CDKN2A/B locus, a new study in Nature Aging identifies CUX1 as a binding protein of an atherosclerosis-associated functional SNP, which activates CDKN2A expression and senescence in endothelial cells, thus providing a mechanism of transcriptional senescence regulation.
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Nat Aging
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2662-8465
2662-8465
2662-8465
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Springer Nature
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Cancer Research UK (24453)