A role for CUX1 in the regulation of p16 and senescence

Chan, Adelyne Sue Li; Narita, Masashi

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Authors

Chan, Adelyne Sue Li

Narita, Masashi

Publication Date

2022-02

Journal Title

Nature Aging

ISSN

2662-8465

Publisher

Springer Science and Business Media LLC

Type

Article

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Citation

Chan, A. S. L., & Narita, M. (2022). A role for CUX1 in the regulation of p16 and senescence. Nature Aging https://doi.org/10.1038/s43587-022-00173-4

Abstract

Vascular senescence has been implicated in atherosclerosis. By characterising SNPs in the p16-encoding CDKN2A/B locus, a new study in Nature Aging identifies CUX1 as a binding protein of an atherosclerosis-associated functional SNP, which activates CDKN2A expression and senescence in endothelial cells, thus providing a mechanism of transcriptional senescence regulation.

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External DOI: https://doi.org/10.1038/s43587-022-00173-4

This record's URL: https://www.repository.cam.ac.uk/handle/1810/332753

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Licence URL: http://www.rioxx.net/licenses/all-rights-reserved

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