A role for CUX1 in the regulation of p16 and senescence.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Chan, Adelyne Sue Li
Narita, Masashi https://orcid.org/0000-0001-7764-577X
Abstract
Vascular senescence has been implicated in atherosclerosis. By characterising SNPs in the p16-encoding CDKN2A/B locus, a new study in Nature Aging identifies CUX1 as a binding protein of an atherosclerosis-associated functional SNP, which activates CDKN2A expression and senescence in endothelial cells, thus providing a mechanism of transcriptional senescence regulation.
Description
Keywords
Repressor Proteins, Up-Regulation
Journal Title
Nat Aging
Conference Name
Journal ISSN
2662-8465
2662-8465
2662-8465
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Publisher
Springer Science and Business Media LLC
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Sponsorship
Cancer Research UK (24453)