Participant characteristics associated with changes in mental health in a trial of behavioural weight management programmes: Secondary analysis of the WRAP trial
Obesity Facts: the European journal of obesity
S. Karger AG
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Jones, R., Mueller, J., Sharp, S., Duschinsky, R., Griffin, S., & Ahern, A. (2022). Participant characteristics associated with changes in mental health in a trial of behavioural weight management programmes: Secondary analysis of the WRAP trial. Obesity Facts: the European journal of obesity https://doi.org/10.1159/000522083
Introduction: On average, aspects of mental health improve following behavioural weight management programmes, yet this is not the case for all participants. It is important to identify those at risk of harm to provide more effective psychological support. We aimed to identify participant characteristics associated with changes in depression and anxiety in participants of a behavioural weight management programme. Methods: In the Weight loss Referrals for Adults in Primary care (WRAP) trial, 1267 adults with BMI≥28 kg/m2 were randomised to brief intervention, or WW (formerly Weight Watchers) for 12-weeks or 52-weeks and followed for five years. We used linear and multinomial regression to explore the association between participant characteristics and changes in depression and anxiety (measured by Hospital Anxiety and Depression Scale). Where possible, the impact of missing data was investigated using multiple imputation. Results: Higher baseline anxiety was associated with decreases in anxiety symptoms and increases in depression symptoms from baseline to follow-up. Higher baseline depression was associated with decreases in depression symptoms and increases in anxiety symptoms from baseline to follow-up. The magnitude of the associations were small. No further characteristics were consistently associated with changes in mental health. Discussion: Evidence suggests that baseline depression and anxiety may indicate how depression and anxiety symptoms change during and after attending WW. Measurement of depression and anxiety at the start of a behavioural weight management programme and subsequent monitoring may facilitate timely psychological support if a deterioration in mental health is identified. Further research in large and diverse participant samples is required to clarify the findings.
The WRAP trial was funded by the National Prevention Research Initiative through research grant MR/J000493. The intervention was provided by WW (formerly Weight Watchers) at no cost via an MRC Industrial Collaboration Award. Five year follow up of the WRAP trial was funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (RP-PG-0216-20010). RAJ, ALA, SJG, and SJS are supported by the Medical Research Council (MRC) (Grant MC_UU_00006/6). The University of Cambridge has received salary support in respect of SJG from the National Health Service in the East of England through the Clinical Academic Reserve.
Department of Health (via National Institute for Health Research (NIHR)) (RP-PG-0216-20010)
External DOI: https://doi.org/10.1159/000522083
This record's URL: https://www.repository.cam.ac.uk/handle/1810/332950
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/