Epigenetics and tissue immunity-Translating environmental cues into functional adaptations.
Publication Date
2022-01Journal Title
Immunol Rev
ISSN
0105-2896
Publisher
Wiley
Volume
305
Issue
1
Pages
111-136
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Tuong, Z. K., Stewart, B. J., Guo, S. A., & Clatworthy, M. R. (2022). Epigenetics and tissue immunity-Translating environmental cues into functional adaptations.. Immunol Rev, 305 (1), 111-136. https://doi.org/10.1111/imr.13036
Abstract
There is an increasing appreciation that many innate and adaptive immune cell subsets permanently reside within non-lymphoid organs, playing a critical role in tissue homeostasis and defense. The best characterized are macrophages and tissue-resident T lymphocytes that work in concert with organ structural cells to generate appropriate immune responses and are functionally shaped by organ-specific environmental cues. The interaction of tissue epithelial, endothelial and stromal cells is also required to attract, differentiate, polarize and maintain organ immune cells in their tissue niche. All of these processes require dynamic regulation of cellular transcriptional programmes, with epigenetic mechanisms playing a critical role, including DNA methylation and post-translational histone modifications. A failure to appropriately regulate immune cell transcription inevitably results in inadequate or inappropriate immune responses and organ pathology. Here, with a focus on the mammalian kidney, an organ which generates differing regional environmental cues (including hypersalinity and hypoxia) due to its physiological functions, we will review the basic concepts of tissue immunity, discuss the technologies available to profile epigenetic modifications in tissue immune cells, including those that enable single-cell profiling, and consider how these mechanisms influence the development, phenotype, activation and function of different tissue immune cell subsets, as well as the immunological function of structural cells.
Keywords
INVITED REVIEW, INVITED REVIEWS, chromatin accessibility, DNA methylation, kidney, macrophage, tissue immunity
Sponsorship
Medical Research Council (MR/S035842/1)
Identifiers
imr13036
External DOI: https://doi.org/10.1111/imr.13036
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333125
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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