Association of triglyceride-glucose index with clinical outcomes in patients with acute ischemic stroke receiving intravenous thrombolysis.
Authors
Toh, Emma MS
Lim, Amanda YL
Ming, Chua
Yeo, Leonard LL
Sia, Ching-Hui
Tan, Bryce WQ
Leow, Aloysius ST
Ho, Jamie SY
Chan, Bernard PL
Sharma, Vijay Kumar
Tan, Benjamin YQ
Publication Date
2022-01-31Journal Title
Sci Rep
ISSN
2045-2322
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Toh, E. M., Lim, A. Y., Ming, C., Yeo, L. L., Sia, C., Tan, B. W., Leow, A. S., et al. (2022). Association of triglyceride-glucose index with clinical outcomes in patients with acute ischemic stroke receiving intravenous thrombolysis.. Sci Rep, 12 (1) https://doi.org/10.1038/s41598-022-05467-6
Abstract
Intravenous tissue plasminogen activator (tPA) remains the cornerstone of recanalization therapy for acute ischemic stroke (AIS), albeit with varying degrees of response. The triglyceride-glucose (TyG) index is a novel marker of insulin resistance, but association with outcomes among AIS patients who have received tPA has not been well elucidated. We studied 698 patients with AIS who received tPA from 2006 to 2018 in a comprehensive stroke centre. TyG index was calculated using the formula: ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. TyG index was significantly lower in patients that survived at 90-days than those who died (8.61 [Interquartile Range: 8.27-8.99] vs 8.76 [interquartile range: 8.39-9.40], p = 0.007). In multivariate analysis, TyG index was significantly associated with 90-day mortality (OR: 2.12, 95% CI: 1.39-3.23, p = 0.001), poor functional outcome (OR: 1.41 95% CI: 1.05-1.90, p = 0.022), and negatively associated with early neurological improvement (ENI) (OR: 0.68, 95% CI: 0.52-0.89, p = 0.004). There was no association between TyG index and symptomatic intracranial hemorrhage. 'High TyG' (defined by TyG index ≥ 9.15) was associated with mortality, poor functional outcomes and no ENI. In conclusion, the TyG index, a measure of insulin resistance, was significantly associated with poorer clinical outcomes in AIS patients who received tPA.
Keywords
Article, /692/617/375/534, /692/163/2743, /692/4019/592/75/593/1370, article
Identifiers
s41598-022-05467-6, 5467
External DOI: https://doi.org/10.1038/s41598-022-05467-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333476
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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