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dc.contributor.authorAlthubaity, Noha
dc.contributor.authorSchubert, Julia
dc.contributor.authorMartins, Daniel
dc.contributor.authorYousaf, Tayyabah
dc.contributor.authorNettis, Maria A
dc.contributor.authorMondelli, Valeria
dc.contributor.authorPariante, Carmine
dc.contributor.authorHarrison, Neil A
dc.contributor.authorBullmore, Edward
dc.contributor.authorDima, Danai
dc.contributor.authorTurkheimer, Federico E
dc.contributor.authorVeronese, Mattia
dc.date.accessioned2022-02-01T01:25:15Z
dc.date.available2022-02-01T01:25:15Z
dc.date.issued2022
dc.identifier.issn2213-1582
dc.identifier.other34972034
dc.identifier.otherPMC8718974
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333488
dc.description.abstractBACKGROUND: Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role in the interaction between the central and peripheral inflammation. Here we aimed to investigate CP volume alterations in depression and their associations with inflammation. METHODS: 51 depressed participants (HDRS score > 13) and 25 age- and sex-matched healthy controls (HCs) from the Wellcome Trust NIMA consortium were re-analysed for the study. All the participants underwent full peripheral cytokine profiling and simultaneous [11C]PK11195 PET/structural MRI imaging for measuring neuroinflammation and CP volume respectively. RESULTS: We found a significantly greater CP volume in depressed subjects compared to HCs (t(76) = +2.17) that was positively correlated with [11C]PK11195 PET binding in the anterior cingulate cortex (r = 0.28, p = 0.02), prefrontal cortex (r = 0.24, p = 0.04), and insular cortex (r = 0.24, p = 0.04), but not with the peripheral inflammatory markers: CRP levels (r = 0.07, p = 0.53), IL-6 (r = -0.08, p = 0.61), and TNF-α (r = -0.06, p = 0.70). The CP volume correlated with the [11C]PK11195 PET binding in CP (r = 0.34, p = 0.005). Integration of transcriptomic data from the Allen Human Brain Atlas with the brain map depicting the correlations between CP volume and PET imaging found significant gene enrichment for several pathways involved in neuroinflammatory response. CONCLUSION: This result supports the hypothesis that changes in brain barriers may cause reduction in solute exchanges between blood and CSF, disturbing the brain homeostasis and ultimately contributing to inflammation in depression. Given that CP anomalies have been recently detected in other brain disorders, these results may not be specific to depression and might extend to other conditions with a peripheral inflammatory component.
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101597070
dc.sourceessn: 2213-1582
dc.subjectBlood brain barrier
dc.subjectDepression
dc.subjectneuroinflammation
dc.subjectChoroid Plexus
dc.titleChoroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression.
dc.typeArticle
dc.date.updated2022-02-01T01:25:15Z
prism.publicationNameNeuroimage Clin
prism.volume33
dc.identifier.doi10.17863/CAM.80908
dcterms.dateAccepted2021-12-21
rioxxterms.versionofrecord10.1016/j.nicl.2021.102926
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.identifier.eissn2213-1582
pubs.funder-project-idWellcome Trust (104025/Z/14/Z)
pubs.funder-project-idMedical Research Council (MC_G0802534)
pubs.funder-project-idMedical Research Council (MR/M009041/1)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International