Assessing Histology Structures by Ex Vivo MR Microscopy and Exploring the Link Between MRM-Derived Radiomic Features and Histopathology in Ovarian Cancer.
Authors
Tardieu, Marion
Lakhman, Yulia
Khellaf, Lakhdar
Cardoso, Maida
Sgarbura, Olivia
Colombo, Pierre-Emmanuel
Crispin-Ortuzar, Mireia
Goze-Bac, Christophe
Nougaret, Stephanie
Publication Date
2021Journal Title
Front Oncol
ISSN
2234-943X
Publisher
Frontiers Media SA
Volume
11
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Tardieu, M., Lakhman, Y., Khellaf, L., Cardoso, M., Sgarbura, O., Colombo, P., Crispin-Ortuzar, M., et al. (2021). Assessing Histology Structures by Ex Vivo MR Microscopy and Exploring the Link Between MRM-Derived Radiomic Features and Histopathology in Ovarian Cancer.. Front Oncol, 11 https://doi.org/10.3389/fonc.2021.771848
Abstract
The value of MR radiomic features at a microscopic scale has not been explored in ovarian cancer. The objective of this study was to probe the associations of MR microscopy (MRM) images and MRM-derived radiomic maps with histopathology in high-grade serous ovarian cancer (HGSOC). Nine peritoneal implants from 9 patients with HGSOC were imaged ex vivo with MRM using a 9.4-T MR scanner. All MRM images and computed pixel-wise radiomics maps were correlated with the slice-matched stroma and tumor proportion maps derived from whole histopathologic slide images (WHSI) of corresponding peritoneal implants. Automated MRM-derived segmentation maps of tumor and stroma were constructed using holdout test data and validated against the histopathologic gold standard. Excellent correlation between MRM images and WHSI was observed (Dice index = 0.77). Entropy, correlation, difference entropy, and sum entropy radiomic features were positively associated with high stromal proportion (r = 0.97,0.88, 0.81, and 0.96 respectively, p < 0.05). MR signal intensity, energy, homogeneity, auto correlation, difference variance, and sum average were negatively associated with low stromal proportion (r = -0.91, -0.93, -0.94, -0.9, -0.89, -0.89, respectively, p < 0.05). Using the automated model, MRM predicted stromal proportion with an accuracy ranging from 61.4% to 71.9%. In this hypothesis-generating study, we showed that it is feasible to resolve histologic structures in HGSOC using ex vivo MRM at 9.4 T and radiomics.
Keywords
Oncology, ovarian cancer, MRI, radiomics, machine learning, histology
Identifiers
External DOI: https://doi.org/10.3389/fonc.2021.771848
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333549
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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