Registry Studies Use Inconsistent Methods to Account for Patients Lost to Follow-up, and Rates of Patients LTFU Are High.
Arthrosc Sports Med Rehabil
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Vemulapalli, K. V., Sunil Kumar, K. H., & Khanduja, V. (2021). Registry Studies Use Inconsistent Methods to Account for Patients Lost to Follow-up, and Rates of Patients LTFU Are High.. Arthrosc Sports Med Rehabil https://doi.org/10.1016/j.asmr.2021.07.016
PURPOSE: To determine methods described in the literature to account for patients lost to follow-up (LTFU) in registry studies and whether rates of patient LTFU are within acceptable margins. METHODS: A scoping review, where a literature search is conducted for studies from 9 arthroscopy registries, was performed on EMBASE, MEDLINE, and the annual reports of each registry. Inclusion criteria included studies with information on patient-reported outcome measures and being based on 9 national registries identified. Exclusion criteria included review articles, conference abstracts, studies not based on registry data, and studies from regional, claims-based, or multicenter registries. Studies were then divided into categories based on method of LTFU analysis used. RESULTS: Thirty-six articles were identified for the final analysis. Categories for LTFU analysis included dropout analyses (n = 10), referencing validation studies (n = 12), contacting nonresponders (n = 4), and sensitivity analyses (n = 1). Referencing validation studies was the most common method (n = 12). Majority (n = 35) of the studies exceeded the recommended maximum rates for LTFU. CONCLUSIONS: Registry studies use inconsistent methods to account for patient LTFU, and rates of patients LTFU are unacceptably high. CLINICAL RELEVANCE: The impact of patients LTFU in studies related to arthroscopic intervention is unknown. A universal method for accounting for patient follow-up is needed.
External DOI: https://doi.org/10.1016/j.asmr.2021.07.016
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333590
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Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/