Advances in the Sensing and Treatment of Wound Biofilms
Authors
Publication Date
2022-03-21Journal Title
Angewandte Chemie
ISSN
0044-8249
Publisher
Wiley
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Darvishi, S., Tavakoli, S., Kharaziha, M., Girault, H. H., Kaminski, C. F., & Mela, I. (2022). Advances in the Sensing and Treatment of Wound Biofilms. Angewandte Chemie https://doi.org/10.1002/ange.202112218
Description
Funder: Medimmune; Id: http://dx.doi.org/10.13039/501100004628
Funder: Infinitus (China) Ltd.
Abstract
Abstract: Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of the biofilm environment. In this review, we present new chemical avenues in biofilm sensors and new materials to treat wound biofilms, offering promise for better detection, chemical specificity, and biocompatibility. We briefly discuss existing methods for biofilm detection and focus on novel, sensor‐based approaches that show promise for early, accurate detection of biofilm formation on wound sites and that can be translated to point‐of‐care settings. We then discuss technologies inspired by new materials for efficient biofilm eradication. We focus on ultrasound‐induced microbubbles and nanomaterials that can both penetrate the biofilm and simultaneously carry active antimicrobials and discuss the benefits of those approaches in comparison to conventional methods.
Keywords
Aufsatz, Aufsätze, biofilms, biosensors, medicinal chemistry, nanotechnology, wound biofilms
Sponsorship
Engineering and Physical Sciences Research Council (EP/H018301/1)
Wellcome Trust (089703/Z/09/Z)
Medical Research Council (MR/K015850/1)
Medical Research Council (MR/K02292X/1)
Engineering and Physical Sciences Research Council (EP/L015889/1)
Identifiers
ange202112218
External DOI: https://doi.org/10.1002/ange.202112218
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333594
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk