Advances in the Sensing and Treatment of Wound Biofilms.
Angew Chem Int Ed Engl
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Darvishi, S., Tavakoli, S., Kharaziha, M., Girault, H. H., Kaminski, C. F., & Mela, I. (2022). Advances in the Sensing and Treatment of Wound Biofilms.. Angew Chem Int Ed Engl https://doi.org/10.1002/anie.202112218
Funder: Medimmune; Id: http://dx.doi.org/10.13039/501100004628
Funder: Infinitus (China) Ltd.
Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of the biofilm environment. In this review, we present new chemical avenues in biofilm sensors and new materials to treat wound biofilms, offering promise for better detection, chemical specificity, and biocompatibility. We briefly discuss existing methods for biofilm detection and focus on novel, sensor-based approaches that show promise for early, accurate detection of biofilm formation on wound sites and that can be translated to point-of-care settings. We then discuss technologies inspired by new materials for efficient biofilm eradication. We focus on ultrasound-induced microbubbles and nanomaterials that can both penetrate the biofilm and simultaneously carry active antimicrobials and discuss the benefits of those approaches in comparison to conventional methods.
Review, Reviews, biofilms, biosensors, medicinal chemistry, nanotechnology, wound biofilms
National Biofilms Innovation Centre (NBIC) (via University of Southampton) (BB/R012415/1 - 03PoC20-105)
Engineering and Physical Sciences Research Council (EP/H018301/1)
Wellcome Trust (089703/Z/09/Z)
Medical Research Council (MR/K015850/1)
Medical Research Council (MR/K02292X/1)
Engineering and Physical Sciences Research Council (EP/L015889/1)
External DOI: https://doi.org/10.1002/anie.202112218
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333595