Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.
Authors
Roe, James M
Düzel, Sandra
Gonzalez, Hector A
Knights, Ethan
Kühn, Simone
Mowinckel, Athanasia M
Nyberg, Lars
Park, Denise C
Rundle, Melissa M
Fjell, Anders M
Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Publication Date
2021-02-01Journal Title
Nat Commun
ISSN
2041-1723
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Roe, J. M., Vidal-Piñeiro, D., Sørensen, Ø., Brandmaier, A. M., Düzel, S., Gonzalez, H. A., Kievit, R. A., et al. (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.. Nat Commun, 12 (1) https://doi.org/10.1038/s41467-021-21057-y
Abstract
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.
Keywords
Article, /631/378/2612, /631/378/1689/1283, /631/378/2611, /59/57, article
Identifiers
s41467-021-21057-y, 21057
External DOI: https://doi.org/10.1038/s41467-021-21057-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333788
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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