Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma
Authors
Publication Date
2022-02Journal Title
Metabolomics
ISSN
1573-3882
Publisher
Springer Science and Business Media LLC
Volume
18
Issue
2
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Furse, S., Watkins, A. J., Williams, H. E., Snowden, S. G., Chiarugi, D., & Koulman, A. (2022). Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma. Metabolomics, 18 (2) https://doi.org/10.1007/s11306-022-01869-9
Abstract
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>The paternal diet affects lipid metabolism in offspring for at least two generations through nutritional programming. However, we do not know how this is propagated to the offspring.</jats:p>
</jats:sec><jats:sec>
<jats:title>Objectives</jats:title>
<jats:p>We tested the hypothesis that the changes in lipid metabolism that are driven by paternal diet are propagated through spermatozoa and not seminal plasma.</jats:p>
</jats:sec><jats:sec>
<jats:title>Methods</jats:title>
<jats:p>We applied an updated, purpose-built computational network analysis tool to characterise control of lipid metabolism systemically (Lipid Traffic Analysis v2.3) on a known mouse model of paternal nutritional programming.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>The analysis showed that the two possible routes for programming effects, the sperm (genes) and seminal plasma (influence on the uterine environment), both have a distinct effect on the offspring’s lipid metabolism. Further, the programming effects in offspring suggest that changes in lipid distribution are more important than alterations in lipid biosynthesis.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>These results show how the uterine environment and genes both affect lipid metabolism in offspring, enhancing our understanding of the link between parental diet and metabolism in offspring.</jats:p>
</jats:sec>
Keywords
Original Article, Nutritional programming, Lipid metabolism, Lipid traffic analysis
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M027252/2)
Biotechnology and Biological Sciences Research Council (BB/M027252/1)
Medical Research Council (MC_UU_12012/4)
Identifiers
s11306-022-01869-9, 1869
External DOI: https://doi.org/10.1007/s11306-022-01869-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333854
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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