Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance.
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Authors
Heldmann, Marcus
Chatterjee, Krishna
Moran, Carla
Rogge, Berenike
Steinhardt, Julia
Wagner-Altendorf, Tobias
Göttlich, Martin
Schacht, Hannes
Schramm, Peter
Brabant, Georg
Münte, Thomas F
Publication Date
2022-01-19Journal Title
Endocr Connect
ISSN
2049-3614
Publisher
Bioscientifica
Volume
11
Issue
1
Pages
e210473
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Heldmann, M., Chatterjee, K., Moran, C., Rogge, B., Steinhardt, J., Wagner-Altendorf, T., Göttlich, M., et al. (2022). Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance.. Endocr Connect, 11 (1), e210473. https://doi.org/10.1530/EC-21-0473
Abstract
BACKGROUND: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone receptor β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly expressing the β form of the receptor (pituitary, liver). This study seeks to identify the effects of mutant TRβ on pituitary size. METHODS: High-resolution 3D T1-weighted magnetic resonance images were acquired in 19 patients with RTHβ in comparison to 19 healthy matched controls. Volumetric measurements of the pituitary gland were performed independently and blinded by four different raters (two neuroradiologists, one neurologist, one neuroscientist). RESULTS: Patients with mutant TRβ (resistance to thyroid hormone β, RTHβ) showed elevated free tri-iodothyronine/thyroxine levels with normal thyroid-stimulating hormone levels, whereas healthy controls showed normal thyroid hormone levels. Imaging revealed smaller pituitary size in RTHβ patients in comparison to healthy controls (F(1,35) = 7.05, P = 0.012, partial η2 = 0.17). CONCLUSION: RTHβ subjects have impaired sensitivity to thyroid hormones, along with decreased size of the pituitary gland.
Keywords
pituitary, thyroid, thyroid hormone receptor, thyroid hormone resistance
Identifiers
External DOI: https://doi.org/10.1530/EC-21-0473
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334181
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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