Parasite co-infection: an ecological, molecular and experimental perspective.
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Publication Date
2022-01-26Journal Title
Proc Biol Sci
ISSN
0962-8452
Publisher
The Royal Society
Volume
289
Issue
1967
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Venter, F., Matthews, K. R., & Silvester, E. (2022). Parasite co-infection: an ecological, molecular and experimental perspective.. Proc Biol Sci, 289 (1967) https://doi.org/10.1098/rspb.2021.2155
Abstract
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with multiple disease agents. These interact with each other and with the host immune system dynamically, with disease outcomes affected by the composition of the community of infecting pathogens, their order of colonization, competition for niches and nutrients, and immune modulation. While pathogen-immune interactions have been detailed elsewhere, here we examine the use of ecological and experimental studies of trypanosome and malaria infections to discuss the interactions between pathogens in mammal hosts and arthropod vectors, including recently developed laboratory models for co-infection. The implications of pathogen co-infection for disease therapy are also discussed.
Keywords
Plasmodium, Parasite, Trypanosoma, Co-infection
Sponsorship
Wellcome Trust (221717/Z/20/Z, 108905/Z/15/Z, 108905/B/15/Z, 103740/Z/14/Z, 206815/Z/17/Z)
Identifiers
PMC8767208, 35042410
External DOI: https://doi.org/10.1098/rspb.2021.2155
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334235
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