Show simple item record

dc.contributor.authorIouranova, Alexandra
dc.contributor.authorGrun, Delphine
dc.contributor.authorRossy, Tamara
dc.contributor.authorDuc, Julien
dc.contributor.authorCoudray, Alexandre
dc.contributor.authorImbeault, Michael
dc.contributor.authorde Tribolet-Hardy, Jonas
dc.contributor.authorTurelli, Priscilla
dc.contributor.authorPersat, Alexandre
dc.contributor.authorTrono, Didier
dc.date.accessioned2022-02-20T02:02:40Z
dc.date.available2022-02-20T02:02:40Z
dc.date.issued2022-01-18
dc.identifier.issn1759-8753
dc.identifier.otherPMC8767690
dc.identifier.other35042549
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334242
dc.description.abstractBACKGROUND: Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to gene regulation in early human development and germ cells. RESULTS: Here, after studying genes driven by the long terminal repeat (LTR) of endogenous retroviruses, we identify the ape-restricted ZNF676 as the sequence-specific repressor of a subset of contemporary LTR12 integrants responsible for a large fraction of transpochimeric gene transcripts (TcGTs) generated during human early embryogenesis. We go on to reveal that the binding of this KZFP correlates with the epigenetic marking of these TEeRS in the germline, and is crucial to the control of genes involved in ciliogenesis/flagellogenesis, a biological process that dates back to the last common ancestor of eukaryotes. CONCLUSION: These results illustrate how KZFPs and their TE targets contribute to the evolutionary turnover of transcription networks and participate in the transgenerational inheritance of epigenetic traits.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101519891
dc.sourceessn: 1759-8753
dc.titleKRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.
dc.typeArticle
dc.date.updated2022-02-20T02:02:39Z
prism.issueIdentifier1
prism.publicationNameMob DNA
prism.volume13
dc.identifier.doi10.17863/CAM.81655
dcterms.dateAccepted2021-12-23
rioxxterms.versionofrecord10.1186/s13100-021-00260-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidImbeault, Michael [0000-0002-0073-0922]
dc.contributor.orcidTrono, Didier [0000-0002-3383-0401]
dc.identifier.eissn1759-8753
pubs.funder-project-idEuropean Research Council (268721,694658)
cam.issuedOnline2022-01-18


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International