Self-reported physical functional health predicts future bone mineral density in EPIC-Norfolk cohort.
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Authors
Perrott, Sarah
Martin, Kathryn
Keevil, Victoria L
Wareham, Nicholas J
Khaw, Kay-Tee
Myint, Phyo Kyaw
Publication Date
2022-01-28Journal Title
Archives of Osteoporosis
ISSN
1862-3522
Publisher
Springer
Volume
17
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Perrott, S., Martin, K., Keevil, V. L., Wareham, N. J., Khaw, K., & Myint, P. K. (2022). Self-reported physical functional health predicts future bone mineral density in EPIC-Norfolk cohort.. Archives of Osteoporosis, 17 (1) https://doi.org/10.1007/s11657-021-01043-z
Abstract
Using a large population sample from the UK, we found that self-reported physical functional health may be used to predict future bone mineral density especially in women. It may be a useful and inexpensive way to identify individuals before further decline in bone mineral density and the risk of fracture. PURPOSE: Self-reported physical functional health may predict bone mineral density (BMD) and thus provide a method to identify people at risk of low BMD. In this study, the association between the 36-item short-form questionnaire (SF-36) physical component summary (PCS) score and future BMD in participants aged 40-79 years enrolled in the European Prospective Investigation of Cancer-Norfolk study was investigated. METHODS: Associations between a participant's SF-36 PCS score, measured 18 months after baseline health check, and broadband ultrasound attenuation (BUA-a measure of BMD), measured 2-5 years after baseline, were examined using sex-specific linear and logistic regression analyses adjusting for age, BMI, medical co-morbidities, lifestyle and socioeconomic factors. RESULTS: Data from 10,203 participants, mean (standard deviation (SD)) age 61.5 (8.9) years (57.4% women), were analysed from 1993 to 2000. For every five points lower PCS score in men and women, there was approximately a 0.5 dB/MHz lower mean BUA. In women, a PCS score of less than one standard deviation (1SD) below the sex-specific mean was associated with having a low BUA (< 1SD below sex-specific mean) and very low BUA (< 2.5SD below the sex specific mean); odds ratio (OR) (95% confidence interval) 1.53 (1.24, 1.88) and 8.28 (2.67, 25.69), respectively. The relationship was lesser so in men; corresponding OR (95% CI) were 1.34 (0.91, 1.98) and 2.57 (0.72, 9.20), respectively. CONCLUSIONS: Self-reported physical functioning predicts BMD in an apparently healthy population, particularly in women. This could potentially provide an inexpensive, simple screening tool to identify individuals at risk of osteoporosis.
Keywords
bone mineral density, Sf-36, Older Adults, Physical Functioning
Sponsorship
Medical Research Council (MC_UU_12015/1)
Medical Research Council (MR/N003284/1)
Medical Research Council (G1000143)
Medical Research Council (G0401527)
Identifiers
PMC8796741, 35089428
External DOI: https://doi.org/10.1007/s11657-021-01043-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334530
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